{"id":28456,"date":"2022-06-06T11:56:08","date_gmt":"2022-06-06T09:56:08","guid":{"rendered":"https:\/\/www.incliva.es\/services\/researcher-services\/scientific-management\/international\/featured-projects\/ttv-guide\/"},"modified":"2024-02-05T09:19:07","modified_gmt":"2024-02-05T07:19:07","slug":"ttv-guide","status":"publish","type":"page","link":"https:\/\/www.incliva.es\/en\/services\/researcher-services\/scientific-management\/international\/featured-projects\/ttv-guide\/","title":{"rendered":"TTV Guide"},"content":{"rendered":"<div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-1 fusion-flex-container nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"background-color: rgba(255,255,255,0);background-position: center center;background-repeat: no-repeat;border-width: 0px 0px 0px 0px;border-color:#e2e2e2;border-style:solid;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start\" style=\"max-width:1248px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-0 fusion_builder_column_2_3 2_3 fusion-flex-column\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><div style=\"text-align:center;\"><span class=\" fusion-imageframe imageframe-none imageframe-1 hover-type-none\" style=\"margin-top:20px;margin-bottom:20px;\"><a class=\"fusion-no-lightbox\" href=\"https:\/\/www.ttv-guide.eu\/\" target=\"_blank\" aria-label=\"ttvguide-logo-rgb\" rel=\"noopener noreferrer\"><img width=\"278\" height=\"103\" src=\"https:\/\/www.incliva.es\/wp-content\/uploads\/2022\/03\/ttvguide-logo-rgb.webp\" class=\"img-responsive wp-image-9884\" srcset=\"https:\/\/www.incliva.es\/wp-content\/uploads\/2022\/03\/ttvguide-logo-rgb-200x74.webp 200w, https:\/\/www.incliva.es\/wp-content\/uploads\/2022\/03\/ttvguide-logo-rgb.webp 278w\" sizes=\"(max-width: 640px) 100vw, 278px\" \/><\/a><\/span><\/div><style type=\"text\/css\">@media only screen and (max-width:1532px) {.fusion-title.fusion-title-1{margin-top:10px!important;margin-bottom:15px!important;}}@media only screen and (max-width:640px) {.fusion-title.fusion-title-1{margin-top:10px!important;margin-bottom:10px!important;}}<\/style><div class=\"fusion-title title fusion-title-1 fusion-title-text fusion-title-size-one\" style=\"margin-top:10px;margin-bottom:15px;\"><div class=\"title-sep-container title-sep-container-left fusion-no-large-visibility fusion-no-medium-visibility fusion-no-small-visibility\"><div class=\"title-sep sep-single sep-solid\" style=\"border-color:#3d44ac;\"><\/div><\/div><h1 class=\"title-heading-left\" style=\"margin:0;\">TTV GUIDE TX<\/h1><div class=\"title-sep-container title-sep-container-right\"><div class=\"title-sep sep-single sep-solid\" style=\"border-color:#3d44ac;\"><\/div><\/div><\/div><div class=\"fusion-text fusion-text-1\" style=\"transform:translate3d(0,0,0);\"><h6>PERSONALISATION OF IMMUNOSUPPRESSION BY MONITORING VIRAL LOAD POST KIDNEY TRANSPLANTATION &#8211; A RANDOMISED CONTROLLED PHASE II TRIAL<\/h6>\n<\/div><div class=\"fusion-text fusion-text-2\" style=\"transform:translate3d(0,0,0);\"><p>If the kidneys stop working a kidney transplant can restore the kidney function. However, the immune system would recognize the new kidney as foreign and attack it. Therefore kidneytransplant recipients need drugs to reduce the function of their immune system. These drugs are<br \/>\ncalled immunosuppressive drugs. If the patients take too much drugs their immune system is weak and they get infections.<\/p>\n<p>Therefore transplant physicians need a tool to quantify the activity of the immune system and optimize the drug dose. The recently discovered TT virus might do this job: TT is naturally occurring in the blood of almost every healthy person and every kidney transplant recipient but it causes no disease. If the immune system is strong, the TT virus load is low; this indicates a risk for organ rejection. If the immune system is weak the TT virus load is high; this indicates a risk for infection.<\/p>\n<p>The quantification of the TT virus load in the blood of kidney transplant recipients might help optimize immunosuppressive drugs and thus reduce infections and rejection. Within the TTV GUIDE TX project TT virus guided dosing of immunosuppressive drugs will be tested in a clinical trial including hundreds of kidney transplant recipients from all over Europe. Once established in routine clinical care, TT virus guidance might reduce thousands of infections and kidney transplant rejection each year. In the future the TT virus might not only help kidney transplant recipients but also patients with liver, heart and lung transplantation and guide therapy in autoimmune, infectious and oncologic diseases.<\/p>\n<p><strong>Consortium<\/strong><\/p>\n<p>TTV GUIDE TX brings together 19 partners, including kidney transplant physicians, clinical virologists, project and clinical trial managers, ethicists and health care industry professionals, from 7 EU countries.<\/p>\n<p><strong>INCLIVA\u2019s role<\/strong><\/p>\n<p>INCLIVA will carry out the quantification of TTV DNA in blood.<\/p>\n<\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"align-self: center;margin-left: auto;margin-right: auto;width:100%;\"><div class=\"fusion-separator-border sep-single\" style=\"border-color:#9da0d2;border-top-width:1px;\"><\/div><\/div><div class=\"fusion-text fusion-text-3\" style=\"transform:translate3d(0,0,0);\"><p><strong>Funding<\/strong><\/p>\n<p><img class=\"size-full wp-image-9856 alignleft\" src=\"https:\/\/www.incliva.es\/wp-content\/uploads\/2022\/03\/EU.jpg\" alt=\"\" width=\"123\" height=\"82\" data-wp-editing=\"1\" \/><\/p>\n<p>TTV GUIDE TX has received funding from the European Union\u2019s Horizon 2020 research and innovation programme under grant agreement no. ID 896932<\/p>\n<\/div><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-builder-column-0{width:66.666666666667% !important;margin-top : 0px;margin-bottom : 20px;}.fusion-builder-column-0 > .fusion-column-wrapper {padding-top : 0px !important;padding-right : 0px !important;margin-right : 2.88%;padding-bottom : 0px !important;padding-left : 0px !important;margin-left : 2.88%;}@media only screen and (max-width:1532px) {.fusion-body .fusion-builder-column-0{width:66.666666666667% !important;}.fusion-builder-column-0 > .fusion-column-wrapper {margin-right : 2.88%;margin-left : 2.88%;}}@media only screen and (max-width:640px) {.fusion-body .fusion-builder-column-0{width:100% !important;}.fusion-builder-column-0 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}<\/style><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-1 fusion_builder_column_1_3 1_3 fusion-flex-column\"><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-justify-content-flex-start fusion-content-layout-column\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;background-color:#f9f9f9;border-width: 0 0 0 2px;border-color:#9DA0D2;border-style:solid;box-shadow:0px 0px ;;padding: 4% 4% 4% 4%;\"><div class=\"fusion-text fusion-text-4\" style=\"transform:translate3d(0,0,0);\"><h5 style=\"text-align: center;\">PROGRAMME<\/h5>\n<p style=\"text-align: center;\">H2020 Health<\/p>\n<\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"align-self: center;margin-left: auto;margin-right: auto;margin-top:10px;margin-bottom:10px;width:100%;\"><div class=\"fusion-separator-border sep-single sep-solid\" style=\"border-color:#9DA0D2;border-top-width:1px;\"><\/div><\/div><div class=\"fusion-text fusion-text-5\" style=\"transform:translate3d(0,0,0);\"><h5 style=\"text-align: center;\">PRINCIPAL INVESTIGATOR<\/h5>\n<p style=\"text-align: center;\">Dr. David Navarro<\/p>\n<\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"align-self: center;margin-left: auto;margin-right: auto;margin-top:10px;margin-bottom:10px;width:100%;\"><div class=\"fusion-separator-border sep-single sep-solid\" style=\"border-color:#9DA0D2;border-top-width:1px;\"><\/div><\/div><div class=\"fusion-text fusion-text-6\" style=\"transform:translate3d(0,0,0);\"><h5 style=\"text-align: center;\">ROLE<\/h5>\n<p style=\"text-align: center;\">Partner<\/p>\n<\/div><div class=\"fusion-text fusion-text-7\" style=\"transform:translate3d(0,0,0);\"><h5 style=\"text-align: center;\">FUNDING<\/h5>\n<p style=\"text-align: center;\">\u20ac 85.625,00<\/p>\n<\/div><div class=\"fusion-text fusion-text-8\" style=\"transform:translate3d(0,0,0);\"><h5 style=\"text-align: center;\">START\/END<\/h5>\n<p style=\"text-align: center;\">2021-2026<\/p>\n<\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"align-self: center;margin-left: auto;margin-right: auto;margin-top:10px;margin-bottom:10px;width:100%;\"><div class=\"fusion-separator-border sep-single sep-solid\" style=\"border-color:#9DA0D2;border-top-width:1px;\"><\/div><\/div><div class=\"fusion-text fusion-text-9\" style=\"transform:translate3d(0,0,0);\"><h5 style=\"text-align: center;\">WEBSITE<\/h5>\n<p style=\"text-align: center;\"><a href=\"https:\/\/www.ttv-guide.eu\/\" target=\"_blank\" rel=\"noopener\">www.ttv-guide.eu<\/a><\/p>\n<\/div><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-builder-column-1{width:33.333333333333% !important;margin-top : 0px;margin-bottom : 20px;}.fusion-builder-column-1 > .fusion-column-wrapper {padding-top : 4% !important;padding-right : 4% !important;margin-right : 5.76%;padding-bottom : 4% !important;padding-left : 4% !important;margin-left : 5.76%;}@media only screen and (max-width:1532px) {.fusion-body .fusion-builder-column-1{width:33.333333333333% !important;order : 0;}.fusion-builder-column-1 > .fusion-column-wrapper {margin-right : 5.76%;margin-left : 5.76%;}}@media only screen and (max-width:640px) {.fusion-body .fusion-builder-column-1{width:100% !important;order : 0;}.fusion-builder-column-1 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}<\/style><\/div><style type=\"text\/css\">.fusion-body .fusion-flex-container.fusion-builder-row-1{ padding-top : 0px;margin-top : 0px;padding-right : 0px;padding-bottom : 0px;margin-bottom : 0px;padding-left : 0px;}<\/style><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":10,"featured_media":0,"parent":9839,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"acf":[],"_links":{"self":[{"href":"https:\/\/www.incliva.es\/en\/wp-json\/wp\/v2\/pages\/28456"}],"collection":[{"href":"https:\/\/www.incliva.es\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.incliva.es\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.incliva.es\/en\/wp-json\/wp\/v2\/users\/10"}],"replies":[{"embeddable":true,"href":"https:\/\/www.incliva.es\/en\/wp-json\/wp\/v2\/comments?post=28456"}],"version-history":[{"count":1,"href":"https:\/\/www.incliva.es\/en\/wp-json\/wp\/v2\/pages\/28456\/revisions"}],"predecessor-version":[{"id":28457,"href":"https:\/\/www.incliva.es\/en\/wp-json\/wp\/v2\/pages\/28456\/revisions\/28457"}],"up":[{"embeddable":true,"href":"https:\/\/www.incliva.es\/en\/wp-json\/wp\/v2\/pages\/9839"}],"wp:attachment":[{"href":"https:\/\/www.incliva.es\/en\/wp-json\/wp\/v2\/media?parent=28456"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}