Research Group on Molecular Imaging and Metabolomics

Oncology Area

Identify new metabolomic markers of tumor aggressiveness in brain cancer

Identify new markers of myocardial infarction

Identify new metabolomic cardiovascular risk markers based on the microbiota-host interaction

Dr. Daniel Monleón Salvadó
Dr. Daniel Monleón Salvadó

Leading, R4

Daniel Monleón Salvadó    

Established, R3
Recognised/Emerging, R2

Serena Pisoni
José Manuel Morales Tatay
Vannina González Marrachelli
Antonio Pellín Carcelén
Mercedes Pardo Tendero

First Stage, R1

Pilar Casanova Querol
Geraldine Rocha Correal
María Martín Grau

Collaborating Researchers

Itziar Pérez Terol


Laura Moreno Morcillo
María Sánchez Sánchez

Administrative assistant
Cardiovascular risk of metabolically healthy obesity in two european populations: prevention potential from a metabolomic study. Wei D, Gonzalez-Marrachelli V, Melgarejo J, Liao C, Hu A, Janssens S, Verhamme P, Van Aelst L, Vanassche T, Redon J, Tellez-Plaza M, Martin-Escudero J, Monleon D, Zhang Z. Cardiovascular Diabetology. 2023 Apr 7;22(1):82. doi: 10.1186/s12933-023-01815-6. PMID: 37029406

Impact of maternal weight gain on the newborn metabolome. Guixeres-Esteve T, Ponce-Zanon F, Morales J, Lurbe E, Alvarez-Pitti J, Monleon D. Metabolites. 2023 Apr 15;13(4):561. doi: 10.3390/metabo13040561. PMID: 37110219

Metabolic effects of early life stress and pre-pregnancy obesity are long-lasting and sex-specific in mice. Brix L, Monleon D, Collado M, Ederveen T, Toksoz I, Bordes J, van Doeselaar L, Engelhardt C, Mitra S, Narayan S, Schmidt M. The European Journal of Neuroscience. 2023 Jul;58(1):2215-2231. doi: 10.1111/ejn.16047. PMID: 37203224

Metabolomic patterns, redox-related genes and metals, and bone fragility endpoints in the Hortega Study. Galvez-Fernandez M, Rodriguez-Hernandez Z, Grau-Perez M, Chaves F, Garcia-Garcia A, Amigo N, Monleon D, Garcia-Barrera T, Gomez-Ariza J, Briongos-Figuero L, Perez-Castrillon J, Redon J, Tellez-Plaza M, Martin-Escudero J. Free Radical Biology & Medicine. 2023 Jan;194:52-61. doi: 10.1016/j.freeradbiomed.2022.11.007. PMID: 36370960

Role of selenium in type 2 diabetes, insulin resistance and insulin secretion. Casanova P, Monleon D. World Journal of Diabetes. 2023 Mar 15;14(3):147-158. doi: 10.4239/wjd.v14.i3.147. PMID: 37035226

Sex dimorphism and metabolic profiles in management of metabolic-associated fatty liver disease. Martin-Grau M, Monleon D. World Journal of Clinical Cases. 2023 Feb 26;11(6):1236-1244. doi: 10.12998/wjcc.v11.i6.1236. PMID: 36926130

Desmoplastic infantile astrocytoma with atypical phenotype, PTEN homozygous deletion and BRAF V600E mutation. Megias J, San-Miguel T, Sanchez M, Navarro L, Monleon D, Calabuig-Farinas S, Morales J, Munoz-Hidalgo L, Roldan P, Cerda-Nicolas M, Lopez-Gines C. Acta Neuropathologica Communications. 2022 Jun 20;10(1):88. doi: 10.1186/s40478-022-01392-x. PMID: 35725578

Gene-environment interaction analysis of redox-related metals and genetic variants with plasma metabolic patterns in a general population from Spain: the Hortega Study. Galvez-Fernandez M, Sanchez-Saez F, Domingo-Relloso A, Rodriguez-Hernandez Z, Tarazona S, Gonzalez-Marrachelli V, Grau-Perez M, Morales-Tatay J, Amigo N, Garcia-Barrera T, Gomez-Ariza J, Chaves F, Garcia-Garcia A, Melero R, Tellez-Plaza M, Martin-Escudero J, Redon J, Monleon D. Redox Biology. 2022 Jun;52:102314. doi: 10.1016/j.redox.2022.102314. PMID: 35460952

Healthy lifestyle, metabolomics and incident type 2 diabetes in a population-based cohort from Spain. Delgado-Velandia M, Gonzalez-Marrachelli V, Domingo-Relloso A, Galvez-Fernandez M, Grau-Perez M, Olmedo P, Galan I, Rodriguez-Artalejo F, Amigo N, Briongos-Figuero L, Redon J, Martin-Escudero J, Monleon-Salvado D, Tellez-Plaza M, Sotos-Prieto M. International Journal of Behavioral Nutrition and Physical Activity. 2022 Jan 27;19(1):8. doi: 10.1186/s12966-021-01219-3. PMID: 35086546

Lipoprotein profiles of fat distribution and its association with insulin sensitivity. Wei D, Marrachelli V, Melgarejo J, Liao C, Janssens S, Verhamme P, Vanassche T, Van Aelst L, Monleon D, Redon J, Zhang Z. Frontiers in Endocrinology. 2022 Oct 25;13:978745. doi: 10.3389/fendo.2022.978745. PMID: 36387872

Liver and white/brown fat dystrophy associates with gut microbiota and metabolomic alterations in 3xTg Alzheimer’s Disease mouse model. Guzzardi M, La Rosa F, Campani D, Collado M, Monleon D, Insilla A, Tripodi M, Zega A, Dattilo A, Brunetto M, Maffei M, Bonino F, Iozzo P. Metabolites. 2022 Mar 22;12(4):278. doi: 10.3390/metabo12040278. PMID: 35448465

Matched paired primary and recurrent meningiomas points to cell-death program contributions to genomic and epigenomic instability along tumor progression. San-Miguel T, Megias J, Monleon D, Navarro L, Munoz-Hidalgo L, Montoliu C, Meri M, Roldan P, Cerda-Nicolas M, Lopez-Gines C. Cancers. 2022 Aug 19;14(16):4008. doi: 10.3390/cancers14164008. PMID: 36011000

Metabolomic analysis of severe osteoarthritis in a Spanish population of women compared to healthy and osteoporotic subjects. Pertusa C, Mifsut D, Morales J, Tarin J, Cano A, Monleon D, Garcia-Perez M. Metabolites. 2022 Jul 24;12(8):677. doi: 10.3390/metabo12080677. PMID: 35893245

Sex dimorphism in the metabolome of metabolic syndrome in morbidly obese individuals. Pisoni S, Marrachelli V, Morales J, Maestrini S, Di Blasio A, Monleon D. Metabolites. 2022 May 6;12(5):419. doi: 10.3390/metabo12050419. PMID: 35629923

Small extracellular vesicles from young adipose-derived stem cells prevent frailty, improve health span, and decrease epigenetic age in old mice. Sanz-Ros J, Romero-Garcia N, Mas-Bargues C, Monleon D, Gordevicius J, Brooke RT, Dromant M, Diaz A, Derevyanko A, Guio-Carrion A, Roman-Dominguez A, Ingles M, Blasco MA, Horvath S, Vina J, Borras C. Science Advances. 2022 Oct 21;8(42):eabq2226. doi: 10.1126/sciadv.abq2226. PMID: 36260670

Analysis of LDL and HDL size and number by nuclear magnetic resonance in a healthy working population: the LipoLab Study.. Pallares-Carratala V, Quesada J, Orozco-Beltran D, Amigo-Grau N, Lopez-Pineda A, Fernandez Gimenez A, Gil-Guillen V, Correig X, Masana L, Monleon Salvado D, Redón Mas J, Pascual R, Carratala-Munuera C. International Journal of Clinical Practice. 2021 Jan;75(1):e13610. doi: 10.1111/ijcp.13610. PMID: 32648987

Bacterial metabolites trimethylamine N-oxide and butyrate as surrogates of small intestinal bacterial overgrowth in patients with a recent decompensated heart failure. Mollar A, Marrachelli V, Nunez E, Monleon D, Bodi V, Sanchis J, Navarro D, Nunez J. Scientific reports. 2021 Mar 17;11(1):6110. doi: 10.1038/s41598-021-85527-5. PMID: 33731747

Dental stem cell signaling pathway activation in response to hydraulic calcium silicate-based endodontic cements: A systematic review of in vitro studies. Sanz J, Rodriguez-Lozano F, Lopez-Gines C, Monleon D, Llena C, Forner L. Dental materials. 2021 Apr;37(4):e256-e268. doi: 10.1016/ PMID: 33573840

Lifelong soya consumption in males does not increase lifespan but increases health span under a metabolic stress such as type 2 diabetes mellitus. Borras C, Abdelaziz KM, Diaz A, Gambini J, Jove M, Lopez-Grueso R, Mas-Bargues C, Monleon D, Pamplona R, Vina J. Mechanisms of Ageing and Development. 2021 Dec;200:111596. doi: 10.1016/j.mad.2021.111596. PMID: 34774606

Moderate Red Wine Consumption Increases the Expression of Longevity-Associated Genes in Controlled Human Populations and Extends Lifespan in Drosophila melanogaster. Gambini J, Gimeno-Mallench L, Olaso-Gonzalez G, Mastaloudis A, Traber M, Monleon D, Borras C, Vina J. Antioxidants. 2021 Feb 16;10(2):301. doi: 10.3390/antiox10020301. PMID: 33669360

Whole-exome sequencing, EGFR amplification and infiltration patterns in human glioblastoma. Lopez-Gines C, Munoz-Hidalgo L, San-Miguel T, Megias J, Trivino J, Calabuig S, Roldan P, Cerda-Nicolas M, Monleon D. American Journal of Cancer Research. 2021 Nov 15;11(11):5543-5558. PMID: 34873478‘ target=’_blank’>34873478

Somatic copy number alterations are associated with EGFR amplification and shortened survival in patients with primary glioblastoma. Muñoz Hidalgo L, San Miguel Diez T, Megias Vericat J, Monleon Salvado D, Navarro Cerveró L, Roldan Badia P, Cerda Nicolas M, Lopez Gines C. Neoplasia. 2020 Jan;22(1):10-21. doi: 10.1016/j.neo.2019.09.001. PMID: 31751860

The Status of EGFR Modulates the Effect of miRNA-200c on ZEB1 Expression and Cell Migration in Glioblastoma Cells. Munoz-Hidalgo L, San-Miguel T, Megias J, Serna E, Calabuig-Farinas S, Monleon D, Gil-Benso R, Cerda-Nicolas M, Lopez-Gines C. International Journal of Molecular Sciences. 2020 Dec 31;22(1):368. doi: 10.3390/ijms22010368. PMID: 33396457

Reference: IDIFEDER/2021/072
Title: Metabolómica automatizada de alto rendimiento para estudios epidemiológicos, búsqueda de biomarcadores y ‘big data’
Funding body: Conselleria de Innovación, Universidades, Ciencia y Sociedad Digital
Principal Investigator: Daniel Monleón Salvadó
Duration: 2021 – 2023
Total budget: 148.572 €
Reference: PID2020-113839RB-I00
Title: Efecto del tratamiento con vesículas extracelulares de células madre de grasa de ratones jóvenes sobre parámetros de envejecimiento y fragilidad en ratones de edad avanzada
Funding body: Ministerio de Ciencia e Innovación
Principal Investigator: Consuelo Borrás Blasco
Duration: 2021 – 2024
Total budget: 181.500 €
Reference: AP-2021-016
Title: BREIC: Identificación de biomarcadores del eje corazón-microbiota-sistema inmune por rmn para la estratificación de pacientes con insuficiencia cardiaca
Funding body: Universidad de Valencia – INCLIVA
Principal Investigator: Vannina González Marrachelli, Anna Mollar Fernández
Duration: 2021 – 2022
Total budget: 4.750 €
Reference: PID2019-108973RB-C22
Title: Metabolomic study of mechanisms for Se-related diabetes and insulin resistance
Funding body: Ministerio de Ciencia e Innovación
Principal Investigator: Daniel Monleón Salvadó, Mónica Simón García
Duration: 2020 – 2023
Total budget: 140000
Reference: PI17/02217
Title: Modelos predictivos en insuficiencia cardíaca con FE preservada-intermedia a partir de información de los registros electrónicos de salud. Valor aditivo de marcadores de metabolómica
Funding body: Instituto de Salud Carlos III – Cofinanciado FEDER
Principal Investigator: Vannina González Marrachelli
Duration: 2018 – 2020
Total budget: 24.200 €
Reference: GV/2018/111
Title: Nuevos nanomateriales como agentes de contraste en IRM y desarrollo de la plataforma de RMN para estudios biomedicos mediante histología correlativa
Funding body: Conselleria de Educación, Cultura y Deporte
Principal Investigator: José Manuel Morales Tatay
Duration: 2018 – 2019
Total budget: 9.500 €
Reference: PCIN-2017-117
Title: Obesidad materna y disfunción cognitiva en la descendencia: papel causa-efecto de la microbiota intestinal y prevención dietética temprana
Funding body: Ministerio de Economía y Competitividad
Principal Investigator: Consuelo Borrás Blasco
Duration: 2017 – 2022
Total budget: 143.000 €
Reference: INTIMIC-085
Title: GUTMOM: Maternal obesity and cognitive dysfunction in the offspring: cause-effect role of the GUT MicrobiOMe and early dietary prevention
Funding body: European Commission. JPI HDHL
Principal Investigator: Patricia Lozzo
Duration: 2017 – 2020
Total budget: 778.240 €
Reference: PIE15/00013
Title: A multidisciplinary Project to advance in basic mechanisms, diagnosis, prediction, and prevention of cardiac damage in reperfused acute myocardial infarction
Funding body: Instituto de Salud Carlos III – Cofinanciado FEDER
Principal Investigator: Vicente Bodí Peris
Duration: 2016 – 2019
Total budget: 589.050 €
+ Info
Title: The interplay between metabolome, epigenome and metabolic syndrome in severe obesity: the influence of sex and age
Doctoral candidate: Pisoni, Serena
Director(s): González Marrachelli, Vannina; Monleon Salvado, Daniel; Di Blasio, Anna Maria
Date of the defense: 12/05/2023
University: Universitat de València

Title: Detección de nuevos marcadores asociados a daño por reperfusión y fibrosis infarto de miocardio validados histopatológicamente mediante análisis multivariante de resonancia magnética multimodal
Doctoral candidate: Pérez Terol, Itziar
Director(s): Monleón Salvadó, Daniel; Morales Tatay, José Manuel
Date of the defense: 21/07/2022
University: Universitat de València

Title: Estudio metabolómico en tejido prostático y orina para el diagnóstico y pronóstico del cáncer de próstata
Doctoral candidate: Panach Navarrete, Jorge
Director(s): Martínez Jabaloyas, José María; Morales Tatay, José Manuel; González Marrachelli Vannina
Date of the defense: 08/04/2022
University: Universitat de València

Title: Estudio metabolómico de la interacción huesped-microbiota intestinal en la enfermedad cardiometabólica. Detección temprana, prevención y tratamiento
Doctoral candidate: Pardo Tendero, María Mercedes
Director(s): Monleón Salvado, Daniel; González Marrachelli, Vannina
Date of the defense: 25/06/2021
University: Universitat de València