Research Group on Genetics of Osteoporosis

Metabolism and Organic Damage Area


Our group’s main objective is the identification of genes and genetic polymorphisms associated with bone phenotypes; mainly bone mineral density, as the main predictor of osteoporosis, and fragility fracture. We are also interested in the identification of miRNAs as biomarkers of fragility fracture and osteoarthritis, as well as the study of the metabolome in both pathologies. Our group has developed translational strategies from animal and cellular models to apply this knowledge to humans. Thus, we have worked with ovariectomized mice as a model of postmenopausal bone loss and with primary osteoblasts obtained from women with fragility fractures and severe osteoarthritis. In both models we have studied differentially expressed genes to obtain candidate genes for study in women. Finally, another objective of the group is the characterization of the type of chromosome duplication, its paternal/maternal origin, global gene expression and miRNAs in patients with chromosome 15 duplication inversion syndrome (Idic-15).

Dr. Miguel Ángel García Pérez
Coordinator
Dr. Miguel Ángel García Pérez
miguel.garcia@uv.es

RESEARCHERS
Leading, R4

Miguel Ángel García Pérez    

Established, R3

Damián Mifsut Miedes

Recognised/Emerging, R2
First Stage, R1
STAFF
Collaborating Researchers

Rosa María Aliaga Corachán

Nurse
Technicians
Administrative assistant
Publications
Allelic variants of the estrogen receptor genes and frailty phenotype in postmenopausal women. Monllor-Tormos A, García-Vigara A, Morgan O, García-Pérez M, Tarín J, Cano A. Climacteric. 2024 Feb 6:1-7. doi: 10.1080/13697137.2024.2306269. PMID: 38318796

Association of the rs17782313, rs17773430 and rs34114122 Polymorphisms of/near MC4R Gene with Obesity-Related Biomarkers in a Spanish Pediatric Cohort. Carrasco-Luna J, Navarro-Solera M, Gombert M, Martín-Carbonell V, Carrasco-García A, Del Castillo-Villaescusa C, García-Pérez M, Codoñer-Franch P. Children. 2023 Jul 14;10(7):1221. doi: 10.3390/children10071221. PMID: 37508717

Both reduced ovarian reserve and severe semen alterations are overrepresented in couples seeking assisted reproductive technology treatment for the first time: a cross-sectional study. Tarin J, Pascual E, Garcia-Perez M, Monllor-Tormos A, Cano A. Reproductive Health. 2023 Aug 16;20(1):117. doi: 10.1186/s12978-023-01666-0. PMID: 37582738

Genetic variants of the vitamin D receptor are related to dynapenia in postmenopausal women. Garcia-Vigara A, Monllor-Tormos A, Garcia-Perez M, Tarin J, Cano A. Maturitas. 2023 May;171:40-44. doi: 10.1016/j.maturitas.2023.03.002. PMID: 37001478

Mediterranean diet for cancer prevention and survivorship. Monllor-Tormos A, Garcia-Vigara A, Morgan O, Garcia-Perez M, Mendoza N, Tarin J, Cano A. Maturitas. 2023 Dec:178:107841. doi: 10.1016/j.maturitas.2023.107841. PMID: 37660598

The covid-19 pandemic and the usability of telehealth in a midlife women’s health integrated care program. Garcia-Vigara A, Martin-Gonzalez V, Carbonell J, Bauset-Castello C, Martinez-Aspas A, Monllor-Tormos A, Garcia-Perez M, Tarin J, Cano A. Maturitas. 2023 Feb;168:7-12. doi: 10.1016/j.maturitas.2022.10.011. PMID: 36370490

It is premature to use postmortem sperm for reproductive purposes: a data-driven opinion. Tarin J, Garcia-Perez M, Cano A. Reproductive Sciences. 2022 Dec;29(12):3387-3393. doi: 10.1007/s43032-022-00874-6. PMID: 35146695

Metabolomic analysis of severe osteoarthritis in a Spanish population of women compared to healthy and osteoporotic subjects. Pertusa C, Mifsut D, Morales J, Tarin J, Cano A, Monleon D, Garcia-Perez M. Metabolites. 2022 Jul 24;12(8):677. doi: 10.3390/metabo12080677. PMID: 35893245

Bazedoxifene increases the proliferation of human arterial endothelial cells but does not affect the expression of cyclins A, B, and D1 and of p27(Kip1). Dudenko D, Gomez R, Garcia-Perez M, Tarin J, Cano A. Gynecological Endocrinology. 2021 Mar;37(3):269-272. doi: 10.1080/09513590.2021.1876653. PMID: 33480311

Improving the cementation of the tibial component in knee arthroplasty: a study of four techniques in the cadaver. Rodriguez-Collell J, Mifsut D, Ruiz-Sauri A, Rodriguez-Pino L, Gonzalez-Soler E, Valverde-Navarro A. Bone & Joint Research. 2021 Aug;10(8):467-473. doi: 10.1302/2046-3758.108.BJR-2020-0524.R1. PMID: 34340533

Positive association of high-density lipoprotein cholesterol with lumbar and femoral neck bone mineral density in postmenopausal women. Zolfaroli I, Ortiz E, Garcia-Perez M, Hidalgo-Mora J, Tarin J, Cano A. Maturitas. 2021 May;147:41-46. doi: 10.1016/j.maturitas.2021.03.001. PMID: 33832646

Serum microRNAs in osteoporotic fracture and osteoarthritis: a genetic and functional study. Pertusa C, Tarin JJ, Cano A, Garcia-Perez MA, Mifsut D. Scientific Reports. 2021 Sep 29;11(1):19372. doi: 10.1038/s41598-021-98789-w. PMID: 34588560

Variants translating reduced expression of the beta estrogen receptor gene were associated with increased carotid intima media thickness: A cross-sectional study in late postmenopausal women. Cano-Marquina AJ, Garcia-Perez MA, Tarin JJ, Maceira AM, Cosin-Sales J, Cano A. Medicine. 2021 Jun 11;100(23):e26216. doi: 10.1097/MD.0000000000026216. PMID: 34115005

Projects
Reference: 826640-VIGOUR
Title: Evidence-Based Guidance to Scale-up Integrated Care in Europe (VIGOUR)
Funding body: Agencia Ejecutiva de Consumidores, Salud, Agricultura y Alimentación
Principal Investigator: Antonio Cano Sánchez, Juan J. Tarín, Miguel Ángel García Pérez
Duration: 2019 – 2021
Total budget: 3.046.024,67
Reference: PI17/01875
Title: Osteoporosis y fractura ósea: identificación de genes asociados y evaluación del papel del metabolismo de la arginina
Funding body: Instituto de Salud Carlos III – Cofinanciado FEDER
Principal Investigator: Miguel Ángel García Pérez
Duration: 2018 – 2021
Total budget: 99.220 €
+ Info
Title: Comparación de las diferentes técnicas de cementación de la bandeja tibial en las prótesis de rodilla
Doctoral candidate: Rodríguez Collell, Juan Ramón
Director(s): Valverde Navarro, Alfonso A; Mifsut Miedes, Damián; Ruiz Saurí, Amparo
Date of the defense: 11/09/2020
University: Universitat de València

Title: Lipidograma y metabolismo óseo, estudio clínico y analítico en la cohorte “CARMEN”
Doctoral candidate: Zolfaroli, Irene
Director(s): García Pérez, Miguel Ángel; Cano Sánchez, Antonio
Date of the defense: 27/02/2019
University: Universitat de València